Welcome to the Mueller lab @ King's College London
Jasmine Wyatt, Yuen Ka Chan, Mateusz Hess, Mahvash Tavassoli*, Manuel M. Müller* (2023). Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse. Chem Sci in press.
Rhys C. Griffiths, Frances R. Smith, Diyuan Li, Jasmine Wyatt, David M. Rogers, Jed E. Long, Lola M. L. Cusin, Patrick J. Tighe, Robert Layfield, Jonathan D. Hirst, Manuel M. Müller, Nicholas J. Mitchell (2023). Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C−C Bond Formation. Chem Eur J 29, e202202503.
S Margiola*, K Gerecht*, MM Müller (2021). Semisynthetic ‘designer’ p53 sheds light on a phosphorylation-acetylation relay. Chem Sci 12, 8563-8570.
T Zhang, K Hansen, A Politis, MM Müller (2020). An unusually rapid protein backbone modification stabilizes the essential bacterial enzyme MurA. Biochemistry 59, 3683–3695.
DOI: 10.1021/acs.biochem.0c00502
J Wyatt, MM Müller, M Tavassoli (2019). Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death. Cancers 11, 1975.
Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW (2019). Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. PNAS 116, 8295-8300.
Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H (2018). HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. PNAS 115 , E876-E885.
Müller MM (2018). Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges. Biochemistry 57, 177-185
DOI: 10.1021/acs.biochem.7b00861
Dann GP, Liszczak GP, Bagert JD, Müller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW (2017). ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature 548, 607-311.
Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW (2016). A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nature Chem Biol 12, 188-193.
doi:10.1038/nchembio.2008
Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW (2016). Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun 7, 10589.
doi:10.1038/ncomms10589
Beh LY, Müller MM, Muir TW, Kaplan N, Landweber LF (2015). DNA-Guided establishment of nucleosome patterns within coding regions of a eukaryotic genome. Genome Res 25, 17271738.
doi:10.1101/gr.188516.114
Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW (2015). Targeted histone peptides: insights into the spatial regulation of the methyltransferase PRC2 by using a surrogate of heterotypic chromatin. Angew Chem Int Ed 54, 6457-6461.
doi:10.1002/ange.201500085
Brown ZZ*, Müller MM*, Jain SU, Allis CD, Lewis PW, Muir TW (2014). Strategy for “detoxification” of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. J Am Chem Soc 136, 13498–13501. * = Co-first authors.
doi:10.1021/ja5060934
Mayer C, Müller MM, Gellman SH, Hilvert D (2014). Building proficient enzymes with foldamer prostheses. Angew Chem Int Ed 53, 6978-6981.
doi:10.1002/anie.201400945
Nguyen UTT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW (2014). Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nat methods 11, 834–840.
doi:10.1038/nmeth.3022
Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD (2013). Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340, 857-861.
doi:10.1126/science.1232245
Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D (2013). Directed evolution of a model primordial enzyme provides insights into the development of the genetic code. PLoS Genet 9, e1003187.
doi:10.1371/journal.pgen.1003187
Müller MM, Kries H, Csuhai E, Kast P, Hilvert D (2010). Design, Selection, and Characterization of a Split Chorismate Mutase. Protein Sci 19, 1000-1010.
doi:10.1002/pro.377
Müller MM, Windsor MA, Pomerantz MW, Gellman SH, Hilvert D (2009). A Rationally Designed Aldolase Foldamer. Angew Chem Int Ed 48, 922-925.
doi:10.1002/ange.200804996
Toscano MD, Müller MM, Hilvert D (2007). Enhancing Activity and Controlling Stereoselectivity in a Designed PLP-Dependent Aldolase. Angew Chem Int Ed 46, 4468-4470.
doi:10.1002/anie.200700710
Reviews
Müller MM (2018). Chemical Protein Synthesis: Strategies and Biological Applications. In: Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology (Westwood, Nelson eds), RSC press.
Müller MM and Muir TW (2015). Histones: At the Crossroads of Peptide and Protein Chemistry. Chem Rev 115, 2296-2349. doi:10.1021/cr5003529.
Patents
Muir TW, Nguyen UTT, Müller MM (2013). DNA Barcoding of Designer Mononucleosome and Chromatin Array Libraries for the Profiling of Chromatin Readers, Writers, Erasers, and Modulators thereof. Patent WO2013184930.