Welcome to the Mueller lab @ King's College London

​​Kinetic Resolution of Epimeric Proteins enables Stereoselective Chemical Mutagenesis

Ablat A, Lawton N, Alam R, Haybes BA, Hossain S, Hicks T, Evans SL, Jarvis JA, Nott TJ, Isaacson RL, Müller MM

J. Am. Chem. Soc. 146, 32, 22622–22628 (2024)

https://doi.org/10.1021/jacs.4c07103

 

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Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases

Ding Y, Lambden E, Peate J, Picken LJ, Rees TW, Perez-Ortiz G, Newgas SA, Spicer LAR, Hicks T, Hess J, Ulmschneider MB, Müller MM, and Barry SM

J Am Chem Soc 146, 16787-16801 (2024).

​https://doi.org/10.1021/jacs.4c04711

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FRET Sensor-Modified Synthetic Hydrogels for Real-Time Monitoring of Cell-Derived Matrix Metalloproteinase Activity using Fluorescence Lifetime Imaging

Yan Z, Kavanagh T, da Silva Harrabi R, Lust ST, Tang C, Beavil RL, Müller MM, Beavil AJ, Ameer-Beg S, da Silva RMP, Gentleman E

Adv Functl Mater 2309711 (2024).

https://doi.org/10.1002/adfm.202309711

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Enzymatic Fluoromethylation as Tool for ATP‐independent Ligation

Peng J, Hughes GR, Müller MM*, Seebeck FP*

Angew Chem Int Ed. 63, e202312104 (2023). 

https://doi.org/10.1002/anie.202312104

 

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Crystal Structure and NMR of an α,δ-Peptide Foldamer Helix Shows Side-Chains are Well Placed for Bifunctional Catalysis : Application as a Minimalist Aldolase Mimic

Lin Q, Lan H, Ma C, Stendall RT, Shankland K, Musgrave RA, Horton PN, Baldauf C, Hofmann H-J, Butts CP, Müller MM, Cobb AJA

Angew Chem Int Ed. 62, e202305326 (2023)

DOI: 10.1002/anie.202305326

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Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse 

Wyatt J, Chan YK, Hess M, Tavassoli M*, Müller MM* 

Chem Sci 14, 3881-3892 (2023).

DOI: 10.1039/D2SC04481A

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Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C−C Bond Formation

Griffiths RC, Smith FR, Li D, Wyatt J, Rogers DM, Long JE, Cusin LML, Tighe PJ, Layfield R, Hirst JD, Müller MM, Mitchell NJ

Chem Eur J 29, e202202503 (2023).

DOI: 10.1002/chem.202202503

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Semisynthetic ‘designer’ p53 sheds light on a phosphorylation-acetylation relay

Margiola S*, Gerecht K*, Müller MM

Chem Sci 12, 8563-8570 (2021).

DOI: 10.1039/D1SC00396H

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An unusually rapid protein backbone modification stabilizes the essential bacterial enzyme MurA

T Zhang, K Hansen, A Politis, MM Müller  

Biochemistry 59, 3683–3695 (2020).

DOI: 10.1021/acs.biochem.0c00502

 

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Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death

J Wyatt, MM Müller, M Tavassoli

Cancers 11, 1975 (2019).

DOI: 10.3390/cancers11121975

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Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase

Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW.

PNAS 116, 8295-8300 (2019).

DOI: 10.1073/pnas.1819029116

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Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2

Ge EJ, Jani KS, Diehl KL, Müller MM, and Muir TW

J Am Chem Soc 141, 15029-15039 (2019).

https://doi.org/10.1021/jacs.9b02321

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HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H

PNAS 115 , E876-E885 (2018).

DOI: 10.1073/pnas.1717509115

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Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges

Müller MM
Biochemistry 57, 177-185 (2018).

DOI: 10.1021/acs.biochem.7b00861

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Chemical Protein Synthesis: Strategies and Biological Applications. In: Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology (Westwood, Nelson eds), RSC press.

Müller MM (2018).

DOI: 10.1039/9781788012805

 

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ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference

Dann GP, Liszczak GP, Bagert JD, Müller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW

Nature 548, 607-311 (2017).

doi:10.1038/nature23671​

 

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A two-state activation mechanism controls the histone methyltransferase Suv39h1

Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW

Nature Chem Biol 12, 188-193 (2016).

doi:10.1038/nchembio.2008

 

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Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW

Nat Commun 7, 10589 (2016).

doi:10.1038/ncomms10589

 

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Histones: At the Crossroads of Peptide and Protein Chemistry

Müller MM and Muir TW

Chem Rev 115, 2296-2349 (2015).

doi:10.1021/cr5003529.

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DNA-Guided establishment of nucleosome patterns within coding regions of a eukaryotic genome

Beh LY, Müller MM, Muir TW, Kaplan N, Landweber LF

Genome Res 25, 17271738 (2015).

doi:10.1101/gr.188516.114

 

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Targeted histone peptides: insights into the spatial regulation of the methyltransferase PRC2 by using a surrogate of heterotypic chromatin

Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW

Angew Chem Int Ed 54, 6457-6461 (2015).

doi:10.1002/ange.201500085

 

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Strategy for “detoxification” of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2

Brown ZZ*, Müller MM*, Jain SU, Allis CD, Lewis PW, Muir TW     * = Co-first authors.

J Am Chem Soc 136, 13498–13501 (2014).

doi:10.1021/ja5060934  

 

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Building proficient enzymes with foldamer prostheses

Mayer C, Müller MM, Gellman SH, Hilvert D

Angew Chem Int Ed 53, 6978-6981 (2014).

doi:10.1002/anie.201400945

 

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Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries

Nguyen UTT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW 

Nat methods 11, 834–840 (2014).

doi:10.1038/nmeth.3022

 

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD

Science 340, 857-861 (2013).

doi:10.1126/science.1232245

 

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Directed evolution of a model primordial enzyme provides insights into the development of the genetic code

Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D

PLoS Genet 9, e1003187 (2013).

doi:10.1371/journal.pgen.1003187

 

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Design, Selection, and Characterization of a Split Chorismate Mutase

Müller MM, Kries H, Csuhai E, Kast P, Hilvert D

Protein Sci 19, 1000-1010 (2010).

doi:10.1002/pro.377

 

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A Rationally Designed Aldolase Foldamer

Müller MM, Windsor MA, Pomerantz MW, Gellman SH, Hilvert D

Angew Chem Int Ed 48, 922-925 (2009).

doi:10.1002/ange.200804996

 

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Enhancing Activity and Controlling Stereoselectivity in a Designed PLP-Dependent Aldolase

Toscano MD, Müller MM, Hilvert D

Angew Chem Int Ed 46, 4468-4470 (2007).

doi:10.1002/anie.200700710

 

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Patents

 

Muir TW, Nguyen UTT, Müller MM (2013). DNA Barcoding of Designer Mononucleosome and Chromatin Array Libraries for the Profiling of Chromatin Readers, Writers, Erasers, and Modulators thereof. Patent WO2013184930.