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Guljannat AblatNeev LawtonThomas Hicks, James Jarvis, Manuel M Müller (2023). Kinetic Resolution of Epimeric Proteins enables Stereoselective Chemical Mutagenesis. ChemRXiv preprint


Jiaming Peng, Gregory R. Hughes, Manuel M. Müller, Florian P. Seebeck (2023). Enzymatic Fluoromethylation as Tool for ATP‐independent Ligation. Angewandte Chemie International Edition. In press. e202312104


Qi LinHao LanChunmiao MaRyan T. StendallKenneth ShanklandRebecca A. MusgravePeter N. HortonCarsten BaldaufHans-Jörg HofmannCraig P. ButtsManuel M. MüllerAlexander John Andre Cobb (2023). Crystal Structure and NMR of an α,δ-Peptide Foldamer Helix Shows Side-Chains are Well Placed for Bifunctional Catalysis : Application as a Minimalist Aldolase Mimic. Angewandte Chemie Int Ed. In press. 

DOI: 10.1002/anie.202305326

Jasmine Wyatt, Yuen Ka Chan, Mateusz Hess, Mahvash Tavassoli*, Manuel M. Müller* (2023). Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse. Chem Sci 14, 3881-3892.

DOI: 10.1039/D2SC04481A

Rhys C. Griffiths, Frances R. SmithDiyuan LiJasmine WyattDavid M. RogersJed E. LongLola M. L. CusinPatrick J. TigheRobert LayfieldJonathan D. HirstManuel M. Müller, Nicholas J. Mitchell (2023). Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C−C Bond FormationChem Eur J 29, e202202503.

DOI: 10.1002/chem.202202503

S Margiola*, K Gerecht*, MM Müller (2021). Semisynthetic ‘designer’ p53 sheds light on a phosphorylation-acetylation relay. Chem Sci 12, 8563-8570.

DOI: 10.1039/D1SC00396H

T Zhang, K Hansen, A Politis, MM Müller (2020). An unusually rapid protein backbone modification stabilizes the essential bacterial enzyme MurA. Biochemistry 59, 3683–3695.

DOI: 10.1021/acs.biochem.0c00502


J Wyatt, MM Müller, M Tavassoli (2019). Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death. Cancers 11, 1975.

DOI: 10.3390/cancers11121975

Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW (2019). Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. PNAS 116, 8295-8300.

DOI: 10.1073/pnas.1819029116


Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H (2018). HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. PNAS 115 , E876-E885.

DOI: 10.1073/pnas.1717509115

Müller MM (2018). Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges. Biochemistry 57, 177-185

DOI: 10.1021/acs.biochem.7b00861


Dann GP, Liszczak GP, Bagert JD, Müller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW (2017). ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature 548, 607-311.


Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW (2016). A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nature Chem Biol 12, 188-193.



Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW (2016). Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun 7, 10589.



Beh LY, Müller MM, Muir TW, Kaplan N, Landweber LF (2015). DNA-Guided establishment of nucleosome patterns within coding regions of a eukaryotic genome. Genome Res 25, 17271738.



Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW (2015). Targeted histone peptides: insights into the spatial regulation of the methyltransferase PRC2 by using a surrogate of heterotypic chromatin. Angew Chem Int Ed 54, 6457-6461.



Brown ZZ*, Müller MM*, Jain SU, Allis CD, Lewis PW, Muir TW (2014). Strategy for “detoxification” of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. J Am Chem Soc 136, 13498–13501. * = Co-first authors.



Mayer C, Müller MM, Gellman SH, Hilvert D (2014). Building proficient enzymes with foldamer prostheses. Angew Chem Int Ed 53, 6978-6981.



Nguyen UTT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW (2014). Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nat methods 11, 834–840.



Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD (2013). Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340, 857-861.



Müller MM, Allison JR, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D (2013). Directed evolution of a model primordial enzyme provides insights into the development of the genetic code. PLoS Genet 9, e1003187.



Müller MM, Kries H, Csuhai E, Kast P, Hilvert D (2010). Design, Selection, and Characterization of a Split Chorismate Mutase. Protein Sci 19, 1000-1010.



Müller MM, Windsor MA, Pomerantz MW, Gellman SH, Hilvert D (2009). A Rationally Designed Aldolase Foldamer. Angew Chem Int Ed 48, 922-925.



Toscano MD, Müller MM, Hilvert D (2007). Enhancing Activity and Controlling Stereoselectivity in a Designed PLP-Dependent Aldolase. Angew Chem Int Ed 46, 4468-4470.






Müller MM (2018). Chemical Protein Synthesis: Strategies and Biological Applications. In: Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology (Westwood, Nelson eds), RSC press.

DOI: 10.1039/9781788012805

Müller MM and Muir TW (2015). Histones: At the Crossroads of Peptide and Protein Chemistry. Chem Rev 115, 2296-2349. doi:10.1021/cr5003529.





Muir TW, Nguyen UTT, Müller MM (2013). DNA Barcoding of Designer Mononucleosome and Chromatin Array Libraries for the Profiling of Chromatin Readers, Writers, Erasers, and Modulators thereof. Patent WO2013184930.

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