Dr. Manuel Müller - Sir Henry Dale Research Fellow
Manuel Müller studied biochemistry at ETH Zurich. After a brief internship with Prof. Andrew Ellington at UT Austin in 2006, Manuel returned to ETH where he completed his PhD in protein engineering and evolution under the supervision of Prof. Donald Hilvert in 2010. For his postdoctoral work, he joined Prof. Tom Muir’s lab in Princeton where he developed and applied chemical biology tools to study chromatin modifying enzymes. Since 2016, Manuel is a Sir Henry Dale Fellow of the Wellcome Trust and Royal Society in the Department of Chemistry at King’s College London.
Sofia Margiola - PhD Student, Department of Chemistry
Sofia studied Chemistry at the University of Crete in Greece, where she obtained her M. Sc in Inorgranic Chemistry in 2016. Her master's thesis was carried out in Prof. Coutsolelos’ Lab in collaboration with Prof. Aukauloo at the University of Paris-Sud. She synthesized porphyrin-ruthenium complexes and explored their catalytic abilities to photo-oxidize organic substrates. She joined the Müller group in January 2017 where she is currently working on the development of a chemical approach to access site-specifically modified proteins to investigate how phosphorylation controls their structure and function.
Karola Gerecht - Postdoc (former PhD Student, LIDo)
Karola is from Germany where she obtained her M.Sc. in Biochemistry from the Technical University Munich. During a research stay with Tom Muir at Princeton, she studied the effects of histone posttranslational modifications on chromatin structure. Karola joined the Müller Lab in 2017 where she is exploring isoaspartate formation in proteins and trying to elucidate how this modification impacts protein function.
Jasmine Wyatt - Joint PhD Student Tavassoli Lab, BRC
Jasmine obtained her BSc in Biochemistry followed by a MRes in Translational Cancer Medicine from King’s College London. Jasmine joined the Müller lab in 2017 where she will be investigating the mechanism of action of a cancer-selective toxin. Specifically, her research focuses on the functional consequences of protein phosphorylation. To do this, she is also working with Professor Mahvash Tavassoli (Molecular Oncology) wherein she will be using state-of-the-art protein transduction methodologies to introduce semi-synthetic toxin derivatives into a range of primary and metastatic cancer cell lines.
Tianze Zhang - PhD Student, CSC
Zhang Tianze is from China where she obtained her bachelors degree in pharmaceutical sciences from Tianjin University. Her graduation thesis was carried out in Prof. Kenneth Woycechowsky's lab on the purification of His-tagged proteins. She joined the Mueller lab in Sept. 2017 and her project is about identifying the structural and functional consequences of protein backbone modifications.
Jonathan Davies - PhD Student
Jonathan completed his BSc in Biochemistry with Biology in 2018, during which he undertook a 9-month ERASMUS internship at the University of Veterinary Medicine in Hanover, Germany. His MRes was completed in the Tate Group group at Imperial College London and focused on characterizing the substrate profile of methionine aminopeptidase 2 using proteomics. In 2019, Jonathan joined the Müller Lab where he will be investigating how protein activity and stability are regulated by post-translational modifications.
Matt (Mateusz) Hess - PhD Student
Matt completed his BSc in Biochemistry in 2019 at Royal Holloway, University of London. His Bachelor thesis focused on protein engineering of SNARE complexes under the supervision of Dr. Mikhail Soloviev. In 2019 he joined Dr. Paul Devlin's lab at Royal Holloway for his MSc by Research, where he analysed plant endophytic microbiomes using Next Generation Sequencing and Machine Learning jointly with PrepWorld Ltd. Matt was associated with SporeGen Ltd. from 2019-2020 as a research scientist, where he worked on the development of Bacillus based therapeutics for Clostridium difficile infections and development of a mucosal vaccine for COVID-19. Matt joined the Müller lab in autumn 2020, where he is set to investigate the effects of PTMs on folding and binding kinetics of a transcription factor, in collaboration with the Politis lab and Fluidic Analytics (Cambridge).
Greg Hughes - Postdoc
Greg studied chemistry with molecular medicine at the University of Hull. For his MChem project he researched porphyrin-protein conjugates in Professor Ross Boyle’s lab. Greg moved to UEA in 2015 to carry out his PhD on a collaborative drug discovery project under the supervision of Dr Andrew Chantry, Professor Philip Bulman Page, Professor Andrew Hemmings and Professor Richard Stephenson. His thesis was based on the development of novel WWP2 ubiquitin ligase inhibitors using biophysical, structural and synthetic approaches. During his PhD, he spent time at Charnwood Molecular as part of his BBSRC iCASE placement. After completing his doctoral studies in 2019, he stayed in the Chantry lab as a research associate continuing the ubiquitin ligase drug discovery project. Greg moved to the Muller lab as a postdoctoral researcher in February 2021, where he is working on developing novel nucleophilic probes to capture protein methyl esters.
Sabrina Hossain - Joint PhD student, Politis lab, BiPAS
Sabrina obtained her M. Sci Biochemistry at the University of Birmingham in 2019. For her master’s project, she worked in Dr Timothy Knowles’ laboratory investigating the structure of the bacterial membrane protein DsbD in its natural lipid environment, using styrene maleic acid lipid particles (SMALPs). In summer 2021, Sabrina joined the Biological Physics Across Scales Centre for Doctoral Training (BiPAS CDT) where she will be undertaking her project co-supervised by Dr Argyris Politis and Dr Manuel Müller. Sabrina’s project will be probing the conformational dynamics that underpin function in intrinsically disordered proteins including p53 using hydrogen-deuterium exchange mass spectrometry (HDX-MS) visualised with data-driven modelling.
Builqis Jahan - MSci student
Builqis is a final-year MSci Chemistry student, whose third-year project involved researching mechanisms of resistance in Gram-negative ESKAPE pathogens, and novel therapeutic treatments, under the supervision of Dr Sarah Barry. She completed an undergraduate research fellowship with Dr Muller in the summer of 2021 where she synthesised a small library of phosphopeptides, to be fed into a p53 protein synthesis pipeline. Builqis returned to the Muller lab shortly thereafter to carry out her MSci project, where she will synthesise wild-type and site-specifically phosphorylated p53 proteins, using a novel semi-synthesis strategy.