Lab Members

Dr. Manuel Müller - Sir Henry Dale Research Fellow

 

Manuel Müller studied biochemistry at ETH Zurich. After a brief internship with Prof. Andrew Ellington at UT Austin in 2006, Manuel returned to ETH where he completed his PhD in protein engineering and evolution under the supervision of Prof. Donald Hilvert in 2010. For his postdoctoral work, he joined Prof. Tom Muir’s lab in Princeton where he developed and applied chemical biology tools to study chromatin modifying enzymes. Since 2016, Manuel is a Sir Henry Dale Fellow of the Wellcome Trust and Royal Society in the Department of Chemistry at King’s College London.

Sofia Margiola - PhD Student, Department of Chemistry

 

Sofia studied Chemistry at the University of Crete in Greece, where she obtained her M. Sc in Inorgranic Chemistry in 2016. Her master's thesis was carried out in Prof. Coutsolelos’ Lab in collaboration with Prof. Aukauloo at the University of Paris-Sud. She synthesized porphyrin-ruthenium complexes and explored their catalytic abilities to photo-oxidize organic substrates. She joined the Müller group in January 2017 where she is currently working on the development of a chemical approach to access site-specifically modified proteins to investigate how phosphorylation controls their structure and function.

Karola Gerecht - Postdoc (former PhD Student, LIDo)

 

Karola is from Germany where she obtained her M.Sc. in Biochemistry from the Technical University Munich. During a research stay with Tom Muir at Princeton, she studied the effects of histone posttranslational modifications on chromatin structure. Karola joined the Müller Lab in 2017 where she is exploring isoaspartate formation in proteins and trying to elucidate how this modification impacts protein function.

Jasmine Wyatt - Joint PhD Student Tavassoli Lab, BRC

Jasmine obtained her BSc in Biochemistry followed by a MRes in Translational Cancer Medicine from King’s College London. Jasmine joined the Müller lab in 2017 where she will be investigating the mechanism of action of a cancer-selective toxin. Specifically, her research focuses on the functional consequences of protein phosphorylation. To do this, she is also working with Professor Mahvash Tavassoli (Molecular Oncology) wherein she will be using state-of-the-art protein transduction methodologies to introduce semi-synthetic toxin derivatives into a range of primary and metastatic cancer cell lines.

Tianze Zhang - PhD Student, CSC

Zhang Tianze is from China where she obtained her bachelors degree in pharmaceutical sciences from Tianjin University. Her graduation thesis was carried out in Prof. Kenneth Woycechowsky's lab on the purification of His-tagged proteins. She joined the Mueller lab in Sept. 2017 and her project is about identifying the structural and functional consequences of protein backbone modifications.

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Jonathan Davies - PhD Student

Jonathan completed his BSc in Biochemistry with Biology in 2018, during which he undertook a 9-month ERASMUS internship at the University of Veterinary Medicine in Hanover, Germany. His MRes was completed in the Tate Group group at Imperial College London and focused on characterizing the substrate profile of methionine aminopeptidase 2 using proteomics. In 2019, Jonathan joined the Müller Lab where he will be investigating how protein activity and stability are regulated by post-translational modifications.

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Matt (Mateusz) Hess - PhD Student
 

Matt completed his BSc in Biochemistry in 2019 at Royal Holloway, University of London. His Bachelor thesis focused on protein engineering of SNARE complexes under the supervision of Dr. Mikhail Soloviev. In 2019 he joined Dr. Paul Devlin's lab at Royal Holloway for his MSc by Research, where he analysed plant endophytic microbiomes using Next Generation Sequencing and Machine Learning jointly with PrepWorld Ltd. Matt was associated with SporeGen Ltd. from 2019-2020 as a research scientist, where he worked on the development of Bacillus based therapeutics for Clostridium difficile infections and development of a mucosal vaccine for COVID-19. Matt joined the Müller lab in autumn 2020, where he is set to investigate the effects of PTMs on folding and binding kinetics of a transcription factor, in collaboration with the Politis lab and Fluidic Analytics (Cambridge).

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Greg Hughes - Postdoc

Greg studied chemistry with molecular medicine at the University of Hull. For his MChem project he researched porphyrin-protein conjugates in Professor Ross Boyle’s lab. Greg moved to UEA in 2015 to carry out his PhD on a collaborative drug discovery project under the supervision of Dr Andrew Chantry, Professor Philip Bulman Page, Professor Andrew Hemmings and Professor Richard Stephenson. His thesis was based on the development of novel WWP2 ubiquitin ligase inhibitors using biophysical, structural and synthetic approaches. During his PhD, he spent time at Charnwood Molecular as part of his BBSRC iCASE placement. After completing his doctoral studies in 2019, he stayed in the Chantry lab as a research associate continuing the ubiquitin ligase drug discovery project. Greg moved to the Muller lab as a postdoctoral researcher in February 2021, where he is working on developing novel nucleophilic probes to capture protein methyl esters.  

Sabrina Hossain - Joint PhD student, Politis lab, BiPAS​

Sabrina obtained her M. Sci Biochemistry at the University of Birmingham in 2019. For her master’s project, she worked in Dr Timothy Knowles’ laboratory investigating the structure of the bacterial membrane protein DsbD in its natural lipid environment, using styrene maleic acid lipid particles (SMALPs). In summer 2021, Sabrina joined the Biological Physics Across Scales Centre for Doctoral Training (BiPAS CDT) where she will be undertaking her project co-supervised by Dr Argyris Politis and Dr Manuel Müller. Sabrina’s project will be probing the conformational dynamics that underpin function in intrinsically disordered proteins including p53 using hydrogen-deuterium exchange mass spectrometry (HDX-MS) visualised with data-driven modelling.

Alumni

Daynea Wallock-Richards - Postdoc

Daynea studied Chemistry and Education at the University of the West Indies. She also completed a MRes degree in Biological and Medicinal Chemistry at the University of Nottingham. Her research project was carried out in Prof. Neil Thomas’ lab. Daynea then completed her doctoral studies at the University of Edinburgh in 2015 under the supervision of Prof. Dominic Campopiano. Her thesis was based on the antimicrobial properties of selected natural products and their protein targets. Daynea joined the Müller research group in 2017 where she is currently working on developing biochemical tools to study backbone modifications of proteins, particularly isoaspartyl-containing proteins.

Current Position: Science Teacher at Leigh Academies
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Niyaz Zaman - LIDo PhD Rotation student

Niyaz completed his BSc in Pharmacology & Molecular Genetics at King’s College London, followed by an MRes in Cancer Biology at Imperial College London. His past projects have focussed along the drug discovery and development pipeline where he has validated targets for immunotherapies, designed and developed gene therapies as well as characterising and validating the targets of chemotherapies, and designing AI/Machine Learning platforms to perform in-silico target prediction and predicting treatment responses based on tumour DNA. In Spring 2021, Niyaz joined the Müller lab on a LIDo PhD rotation to design and characterise cyclic cancer-selective toxins, in collaboration with Professor Mahvash Tavassoli (Molecular Oncology) where these cyclic toxins will be investigated in a range of primary and metastatic cancer cell lines.

Yasmin Gariba-Hamilton - King's MSci Student

Yasmin is currently in her final year of studying MSci Chemistry at King’s College London. She joined the Müller Group in October 2020, wherein her project focuses on the significance of the conversion of certain asparagine/aspartate residues into isoaspartate. Specifically, she will be looking for this change in a protein with identified potential for isoAsp conversion, and considering the impact on its functionality upon this alteration.

Olga Tereszkowska-Kaminska - Undergraduate Student, KCL
Current Position: Undergraduate student at KCL
Florence Stoffel - KURF Student, KCL
Current Position: MSci student at EPFL, Switzerland
Rashi Benarroch - MSci and KURF Student, KCL
Current Position: PhD student at Imperial College

George Preston - Visiting Postdoc, Phillips Lab

George is a visiting postdoc from Prof. David Phillips’ group in the Faculty of Life Sciences & Medicine. In the Mueller lab he is developing molecular probes to target reactive loci of proteins in human blood. The aim is to identify loci at which toxicologically-relevant covalent modifications might be found.

Current Position: Postdoc, Phillips lab @ KCL

Halime Karakoy - King's MSci student