Lab Members

Dr. Manuel Müller - Sir Henry Dale Research Fellow

 

Manuel Müller studied biochemistry at ETH Zurich. After a brief internship with Prof. Andrew Ellington at UT Austin in 2006, Manuel returned to ETH where he completed his PhD in protein engineering and evolution under the supervision of Prof. Donald Hilvert in 2010. For his postdoctoral work, he joined Prof. Tom Muir’s lab in Princeton where he developed and applied chemical biology tools to study chromatin modifying enzymes. Since 2016, Manuel is a Sir Henry Dale Fellow of the Wellcome Trust and Royal Society in the Department of Chemistry at King’s College London.

Sofia Margiola - PhD Student, Department of Chemistry

 

Sofia studied Chemistry at the University of Crete in Greece, where she obtained her M. Sc in Inorgranic Chemistry in 2016. Her master's thesis was carried out in Prof. Coutsolelos’ Lab in collaboration with Prof. Aukauloo at the University of Paris-Sud. She synthesized porphyrin-ruthenium complexes and explored their catalytic abilities to photo-oxidize organic substrates. She joined the Müller group in January 2017 where she is currently working on the development of a chemical approach to access site-specifically modified proteins to investigate how phosphorylation controls their structure and function.

Karola Gerecht - PhD Student, LIDo

 

Karola is from Germany where she obtained her M.Sc. in Biochemistry from the Technical University Munich. During a research stay with Tom Muir at Princeton, she studied the effects of histone posttranslational modifications on chromatin structure. Karola joined the Müller Lab in 2017 where she is exploring isoaspartate formation in proteins and trying to elucidate how this modification impacts protein function.

Daynea Wallock-Richards - Postdoc

Daynea studied Chemistry and Education at the University of the West Indies. She also completed a MRes degree in Biological and Medicinal Chemistry at the University of Nottingham. Her research project was carried out in Prof. Neil Thomas’ lab. Daynea then completed her doctoral studies at the University of Edinburgh in 2015 under the supervision of Prof. Dominic Campopiano. Her thesis was based on the antimicrobial properties of selected natural products and their protein targets. Daynea joined the Müller research group in 2017 where she is currently working on developing biochemical tools to study backbone modifications of proteins, particularly isoaspartyl-containing proteins.

Current Position: Science Teacher at Leigh Academies
Jasmine Wyatt - Joint PhD Student Tavassoli Lab, BRC

Jasmine obtained her BSc in Biochemistry followed by a MRes in Translational Cancer Medicine from King’s College London. Jasmine joined the Müller lab in 2017 where she will be investigating the mechanism of action of a cancer-selective toxin. Specifically, her research focuses on the functional consequences of protein phosphorylation. To do this, she is also working with Professor Mahvash Tavassoli (Molecular Oncology) wherein she will be using state-of-the-art protein transduction methodologies to introduce semi-synthetic toxin derivatives into a range of primary and metastatic cancer cell lines.

Tianze Zhang - PhD Student, CSC

Zhang Tianze is from China where she obtained her bachelors degree in pharmaceutical sciences from Tianjin University. Her graduation thesis was carried out in Prof. Kenneth Woycechowsky's lab on the purification of His-tagged proteins. She joined the Mueller lab in Sept. 2017 and her project is about identifying the structural and functional consequences of protein backbone modifications.

Florence Stoffel - KURF Student, KCL
Current Position: MSci student at EPFL, Switzerland

Alumni

Rashi Benarroch - MSci and KURF Student, KCL
Current Position: PhD student at Imperial College

George Preston - Visiting Postdoc, Phillips Lab

George is a visiting postdoc from Prof. David Phillips’ group in the Faculty of Life Sciences & Medicine. In the Mueller lab he is developing molecular probes to target reactive loci of proteins in human blood. The aim is to identify loci at which toxicologically-relevant covalent modifications might be found.

Current Position: Postdoc, Phillips lab @ KCL

Halime Karakoy - King's MSci student
Jonathan Davies - PhD Student

Jonathan completed his BSc in Biochemistry with Biology in 2018, during which he undertook a 9-month ERASMUS internship at the University of Veterinary Medicine in Hanover, Germany. His MRes was completed in the Tate Group group at Imperial College London and focused on characterizing the substrate profile of methionine aminopeptidase 2 using proteomics. In 2019, Jonathan joined the Müller Lab where he will be investigating how protein activity and stability are regulated by post-translational modifications.

Manuel Mueller - King's College London

© Müller Lab 2016